Compact Microfluidic Structures for Generating Spatial and Temporal Gradients

Compact microfluidic structures for generating spatial and temporal gradients.

We present an improved microfluidic design for generating spatial and temporal gradients. The basic functional elements are bifurcated and trifurcated channels used to split flow between two and three channels, respectively. We use bifurcated channels on the exterior of the channel manifold and trifurcated channels in the interior with mixing tees to recombine flows. For N gradient-forming leve...

Analysis of Temporal and Spatial Temperature Gradients for IC Reliability

One of the most common causes of IC failure is interconnect electromigration (EM), which exhibits a rate that is exponentially dependent on temperature. As a result, EM rate is one of the major determinants of the maximum tolerable operating temperature for an IC and of resulting cooling costs. Previous EM models have assumed a uniform, typically worst-case, temperature. This paper presents a m...

Planning for Protected Areas Using Spatial and Temporal Metrics

Generating multiplex gradients of biomolecules for controlling cellular adhesion in parallel microfluidic channels.

Here we present a microfluidic platform to generate multiplex gradients of biomolecules within parallel microfluidic channels, in which a range of multiplex concentration gradients with different profile shapes are simultaneously produced. Nonlinear polynomial gradients were also generated using this device. The gradient generation principle is based on implementing parrallel channels with each...

Spatial and temporal gradients in the cosmological constant

It is possible that there may be differences in the fundamental physical parameters from one side of the observed universe to the other. I show that the cosmological constant is likely to be the most sensitive of the physical parameters to possible spatial variation, because a small variation in any of the other parameters produces a huge variation of the cosmological constant. It therefore pro...